Postdoctoral Scientist – PNAC (Dr Noe Rodriguez) – LMB 2794
MRC Laboratory of Molecular Biology (LMB)
Cambridge, United Kingdom
General Description
The MRC Laboratory of Molecular Biology (LMB) is seeking a highly motivated Postdoctoral Scientist to join the research group led by Dr Noe Rodriguez. This position focuses on investigating the molecular mechanisms of protein–nucleic acid complexes (PNACs) using advanced structural biology approaches. The role offers the opportunity to work within one of the world’s leading institutes for molecular biology research, known for groundbreaking discoveries and cutting-edge technological innovation.
The successful candidate will contribute to research aimed at understanding the structural and functional mechanisms underlying protein–nucleic acid interactions. The project will involve the use of state-of-the-art structural biology techniques, particularly cryo-electron microscopy (cryo-EM), alongside complementary biochemical and biophysical methods. The research aims to reveal how macromolecular complexes involved in nucleic acid metabolism are assembled and regulated at the molecular level.
The postholder will design and conduct experiments, analyse complex structural and biochemical data, and contribute to the development of new experimental approaches for studying large molecular assemblies. Responsibilities include preparing samples, performing cryo-EM data collection and analysis, conducting biochemical assays, and interpreting results within the context of protein–nucleic acid complex function. The role also involves preparing scientific manuscripts, presenting findings at scientific meetings, and collaborating with other researchers within the LMB and external institutions.
The MRC Laboratory of Molecular Biology provides an exceptional research environment with access to advanced facilities and expertise across structural biology, molecular biology, and computational analysis. The institute supports interdisciplinary collaboration and encourages innovative approaches to fundamental biological questions.
The appointment is offered as a fixed-term contract within the LMB research programme and provides an excellent opportunity for early-career researchers to develop their independent research profile while working within a globally recognised centre of scientific excellence.
Eligibility Criteria
PhD in Structural Biology, Biochemistry, Molecular Biology, Biophysics, or a closely related discipline
Demonstrated research experience in structural biology or related molecular sciences
Evidence of the ability to conduct independent research and contribute to high-quality scientific publications
Strong academic background in protein–nucleic acid interactions or related molecular mechanisms
Required Expertise/Skills
Experience with cryo-electron microscopy (cryo-EM) or other structural biology techniques
Knowledge of biochemical and biophysical methods for studying macromolecular complexes
Experience with protein purification and sample preparation
Ability to analyse and interpret complex experimental data
Strong problem-solving and analytical skills
Excellent written and verbal communication skills for scientific reporting and presentations
Ability to work both independently and collaboratively within multidisciplinary research teams
Salary Details
£39,375 – £45,938 per annum
Application Deadline
16 March 2026