PhD Studentship – Exploring the Molecular Mechanisms of Nutrient Utilisation in Mycobacterium tuberculosis
The University of Manchester
Manchester, United Kingdom
General Description
The University of Manchester’s Department of Chemistry (in collaboration with the Manchester Institute of Biotechnology) invites applications for a fully funded PhD Studentship focused on understanding how Mycobacterium tuberculosis acquires and utilises nutrients to sustain infection and survival within the human host. Tuberculosis (TB) remains a leading global health threat, responsible for over a million deaths annually, driven by the pathogen’s remarkable ability to persist in diverse host environments. This interdisciplinary project integrates biochemistry, chemistry, structural biology, biophysics and microbiology to identify key nutrients used by M. tuberculosis, determine mechanisms of nutrient uptake, and decipher how these nutrients are metabolised. The research aims to generate new insights into host‑pathogen interactions and uncover potential targets for next‑generation TB therapeutics and diagnostics. The successful candidate will conduct research in an internationally collaborative environment with access to world‑class facilities and multidisciplinary training. This PhD project is structured for home students and eligible international/EU candidates with settled status and spans approximately 3.5 years with the potential for flexible start dates.
Eligibility Criteria
Applicants should hold, or be expected to obtain, at least a 2:1 honours degree (UK or equivalent) in chemistry, biochemistry, molecular biology, microbiology or a closely related discipline. A Master’s qualification with merit or distinction is advantageous. Candidates with a strong interest in pathogen biochemistry and microbial nutrient utilisation are encouraged to apply. Research experience in relevant laboratory techniques is beneficial but not mandatory.
Required Expertise/Skills
Demonstrated academic grounding in biological chemistry, microbiology, biochemistry or related sciences.
Strong analytical skills and a motivated research mindset.
Interest in interdisciplinary approaches combining biochemical, chemical and structural techniques.
Effective written and oral communication skills suitable for research dissemination.
Salary Details
This studentship is fully funded, including payment of tuition fees and an annual tax‑free stipend at the UKRI rate (approximately £20,780 for the 2025/26 academic year). Stipend increases may occur in subsequent years in line with UKRI guidelines. Relocation and associated costs are the candidate’s responsibility unless additional support is available through separate funding sources.
Application Deadline
Application deadlines can vary; early applications are recommended as the advert may be removed once the position is filled. Specific deadline details are typically listed within the University of Manchester application portal.