Durham University – Department of Chemistry
Durham, United Kingdom

This fully funded doctoral studentship invites a highly motivated researcher to embark on a unique interdisciplinary project at Durham University’s Department of Chemistry. The research focuses on elucidating the molecular interactions between human acetylcholinesterase (AChE), a key enzyme in neurotransmission, and specially designed low-toxicity carbamate analogues. While acetylcholinesterase plays a central role in nerve signal transmission and is a validated drug target in neurodegenerative diseases, the mechanisms by which certain carbamate inhibitors interact with AChE — particularly those with high toxicity — remain poorly understood. This PhD project aims to deepen foundational knowledge of these interactions by synthesising a diverse library of non-toxic carbamate analogues and analysing how they bind to AChE. Students will apply a suite of experimental methods including quantitative spectroscopy to assess binding interactions and advanced protein crystallisation techniques to determine structural complexes. Work will be conducted in collaboration with supervisors at Durham and scientists from the Defence Science and Technology Laboratory (DSTL), offering exposure to both academic and applied research environments. Participants will also benefit from opportunities to attend training courses and scientific conferences to build their professional networks.

Eligibility Criteria
This opportunity is open to UK students only. Applicants should hold, or be expected to receive, a first or upper second class (2.1) Master’s degree (or equivalent) in Chemistry or a closely related discipline. A minimum 2:1 Honours undergraduate degree is the standard entry requirement, though demonstrated research experience and independent research potential will also be considered.

Required Expertise and Skills
Candidates should possess strong capabilities in synthetic organic chemistry, particularly in the synthesis, purification and analysis of target compounds. Experience with handling and preparation of proteins is beneficial. The project also requires analytical skills for evaluating enzyme-analogue binding using biophysical assays, kinetic analysis and X-ray crystallographic techniques. Excellent verbal and written communication skills and the ability to work both independently and collaboratively are essential.

Salary Details
The studentship is fully funded for a four-year duration at standard UK Research and Innovation (UKRI) rates under an EPSRC Industrial Doctoral Landscape Award with the Defence Science and Technology Laboratory.

Application Deadline
Applications must be submitted by 5 pm on Monday, 23 February 2026.

Application Link – Applicants should apply
annmarie.odonoghue@durham.ac.uk

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