Postdoctoral Position – Transthyretin Amyloid Formation Using X-Rays, Neutrons and Electron Microscopy
Lund University
Lund, Sweden
This opening offers a compelling research opportunity for early-career scientists to join an advanced structural biology initiative focused on a critical challenge in biomedical science: understanding the molecular mechanisms that drive amyloid formation from transthyretin, a protein whose misfolding leads to serious conditions affecting the heart and nervous system. The project centres on cutting-edge biophysical techniques, including X-ray and neutron crystallography, small-angle scattering (SAXS & SANS), and cryo-electron microscopy, to probe structural factors underlying protein stability and pathological transformation. Work will span studies of wild-type transthyretin and clinically relevant mutants, potentially integrating comparative analyses with ex vivo amyloid material. The role is integrated within the Molecular Biophysics group in the Department of Experimental Medical Science at the Faculty of Medicine, with access to world-class facilities such as MAX-IV and the European Spallation Source in Sweden, as well as international beamlines at ESRF and ILL in Europe. This position is part of the Marie Skłodowska-Curie COFUND programme AMBER, which fosters interdisciplinary research across imaging modalities and supports career development within a network of partner institutions.
Applicants must hold a PhD (or equivalent) in physical sciences, molecular biology, biochemistry, structural biology, or a closely related discipline, completed by the start date of employment. Candidates should demonstrate relevant experience in experimental methods central to the project, such as protein expression and purification, crystallisation, and biophysical characterisation, and be proficient in handling diffraction data and structural analysis workflows. Compliance with the Marie Skłodowska-Curie mobility rule is required, and at least one peer-reviewed publication is expected. The role demands a motivated researcher capable of working independently and collaboratively, with strong communication skills in English and the ability to engage with international research activities.
Expertise in structural biology techniques such as X-ray and neutron diffraction, SAXS/SANS, and cryo-EM is essential, alongside practical competence in laboratory research involving sample preparation, data collection and interpretation. Experience with advanced data processing and structure refinement tools, as well as familiarity with collaborative research in interdisciplinary environments, will support success in this role.
While specific salary details are not provided in the public listing, employment as a postdoctoral researcher at Lund University under the Swedish public sector framework includes benefits such as generous holiday entitlement, a favourable occupational pension scheme and flexible working arrangements.
The position is offered on a full-time, fixed-term basis for three years, with an anticipated start in September 2026 or as agreed, and requires presence on site in Lund, Sweden.