Postdoctoral Research Associate
University of York – Department of Chemistry
York, United Kingdom
The University of York is seeking a highly motivated Postdoctoral Research Associate to join the York Structural Biology Laboratory (YSBL) within the Department of Chemistry. This full-time, fixed-term position focuses on the structural characterisation of macromolecular complexes involved in bacteriophage replication initiation. The role will be undertaken in collaboration with the School of Biosciences at the University of Sheffield and is funded by the Engineering and Physical Sciences Research Council (EPSRC).
The successful candidate will contribute to cutting-edge research exploring protein-primed replication mechanisms in bacteriophages such as phi29 and PRD1, with applications in biocatalysis. Key responsibilities include purifying and assembling macromolecular complexes, optimising experimental conditions, and determining cryo-electron microscopy (cryo-EM) structures of replication initiation complexes across different states. The role also provides opportunities to support and supervise postgraduate students, contributing to teaching and mentorship within the research group.
The Department of Chemistry at York is one of the university’s largest and most research-intensive departments, hosting a vibrant community of approximately 85 postdoctoral researchers. The department is ranked among the top 10 in the UK (REF2021) and holds an Athena Swan Gold Award, reflecting its strong commitment to equality, diversity, and inclusion. The University offers a supportive and collaborative environment with flexible and family-friendly working arrangements.
Eligibility Criteria
Applicants must hold a PhD (or be close to completion) in structural biology, biochemistry, or a related discipline, or possess equivalent research experience.
Required Expertise/Skills
- Demonstrated hands-on experience in cryo-EM structure determination, including sample preparation, grid preparation, data collection, structure analysis, and molecular modelling
- Proficiency in biochemical and biophysical techniques such as kinetics analysis, isothermal titration calorimetry (ITC), and microscale thermophoresis (MST)
- Ability to work independently as well as collaboratively within interdisciplinary teams
- Strong scientific communication skills, with evidence of publications and conference presentations
- Commitment to equality, diversity, and inclusion in research environments
Salary Details
£37,694 to £46,049 per annum
Application Deadline
23 February 2026