PhD Studentship – Understanding Heme Enzyme Mechanism Using Dynamic, Time-Resolved Crystallography and QM/MM Simulations
The University of Manchester – Department of Chemistry
Manchester, United Kingdom
General Description – include all relevant details from the source
The University of Manchester’s Department of Chemistry is offering a fully funded PhD studentship in Understanding Heme Enzyme Mechanism Using Dynamic, Time-Resolved Crystallography and QM/MM Simulations. This doctoral research project will explore the catalytic mechanisms of heme enzymes through state-of-the-art experimental and computational approaches. The research combines dynamic, time-resolved crystallography techniques with hybrid quantum mechanical/molecular mechanical (QM/MM) simulations to capture and interpret structural and mechanistic details of enzyme reactions at atomic resolution. The successful candidate will have opportunities to engage with cutting-edge structural biology tools and advanced computational modelling to elucidate how heme enzymes function, providing fundamental insights that have broad relevance to biochemistry and catalysis research. This studentship is situated within a supportive research environment and aligned with internationally recognised expertise in enzymology and structural chemistry at The University of Manchester.
Eligibility Criteria
Applicants should hold, or be expected to obtain, a high-quality undergraduate degree (typically a UK 2:1 or first class) or a relevant postgraduate qualification in Chemistry, Biochemistry, Physics, Structural Biology, Computational Chemistry, or a closely related discipline. Prospective candidates must demonstrate strong academic accomplishments and readiness for independent research in an interdisciplinary setting.
Required expertise/skills
Suitable candidates will have a strong foundation in chemical and structural principles, with experience or demonstrable interest in techniques such as X-ray crystallography, structural biology, molecular simulations, and computational modelling. Skills in QM/MM simulation methods and familiarity with biochemical enzymology are desirable. A commitment to rigorous scientific inquiry and capacity for collaborative research across experimental and theoretical domains are essential.
Salary details
The studentship includes a tax-free annual stipend set at the UKRI research council rate (currently £20,780 per annum) with tuition fees covered at the UK (home) rate.
Application Deadline
Applications for this studentship close on 23 March 2026.